Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs)

Eur J Med Chem. 2010 Dec;45(12):5919-25. doi: 10.1016/j.ejmech.2010.09.057. Epub 2010 Oct 20.

Abstract

N-arylsulfonyl-based MMPs inhibitors (MMPIs) are among the most prominent inhibitors possessing nanomolar affinity. However, their poor bioavailability remains critical for the drug development of this family of molecules. The structural analysis of the complex of NNGH (the most representative member of the family) with MMP-12 provided us with the basis to effectively design simple NNGH analogues with enhanced solubility in water. Following this approach, the sec-butyl residue, not directly involved in the binding with MMP, has been replaced with hydrophilic residues thus yielding new potent inhibitors soluble in water.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Matrix Metalloproteinase Inhibitors
  • Models, Molecular
  • Molecular Structure
  • Nanostructures / chemistry*
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology
  • Solubility
  • Stereoisomerism
  • Structure-Activity Relationship
  • Sulfones / chemical synthesis
  • Sulfones / chemistry*
  • Sulfones / pharmacology
  • Water / chemistry

Substances

  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • Sulfones
  • Water